肌萎缩侧索硬化
疾病
医学
重症监护医学
分子病理学
精密医学
病理
生物信息学
神经科学
心理学
生物
生物化学
基因
作者
Hristelina Ilieva,Mithila Vullaganti,Justin Kwan
标识
DOI:10.1136/bmj-2023-075037
摘要
Abstract Although the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterization, diagnosis, imaging, and biomarkers, along with the current status of approaches to ALS care and treatment. Additional knowledge of the factors driving disease progression and heterogeneity will hopefully soon transform the care for patients with ALS into an individualized, multi-prong approach able to prevent disease progression sufficiently to allow for a dignified life with limited disability.
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