医学
联想(心理学)
白细胞介素
内科学
病理
免疫学
细胞因子
认识论
哲学
作者
Zhongyuan He,Nguyen Tran Canh Tung,Yasuhito Yahara,Hiroto Makino,Taketoshi Yasuda,Shoji Seki,Kayo Suzuki,Hayato Futakawa,Katsuhiko Kamei,Yoshiharu Kawaguchi
出处
期刊:Rheumatology
[Oxford University Press]
日期:2023-10-27
被引量:1
标识
DOI:10.1093/rheumatology/kead555
摘要
To investigate the relationship between the severity and morphology of heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum interleukin-17 (IL-17) levels in patients with ossification of the posterior longitudinal ligament (OPLL) with or without diffuse idiopathic skeletal hyperostosis (DISH), as well as a non-OPLL group.A total of 103 patients with OPLL (DISH (-), n = 50; DISH (+), n = 53) and 53 age- and gender-matched controls were included. The serum levels of IL-17 were analyzed, and the severity of ectopic ossification and the morphology of ectopic bone formation were evaluated. The SI joint morphological variations were categorized into four types.No significant differences were found in serum IL-17 levels between the OPLL and control groups. However, the DISH (+) group showed higher IL-17 levels than the DISH (-) group, especially in female patients (p = 0.003). Additionally, IL-17 levels were positively correlated with the number of Flat vertebral units, meaning one of the characteristics of DISH ossification type (R2 = 0.199, p = 0.012). IL-17 levels in type 4 were significantly higher in the DISH (+) group than in the DISH (-) group.The morphological characteristics of paravertebral bone formation in the entire spine, including the SI joint, are likely associated with serum IL-17 levels in OPLL. These findings provide pathological and serological evidence of local inflammation contributing to paravertebral ossification of OPLL patients.
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