One-step Preparation of Antibacterial Gelatin/Polycaprolactone Nanofibrous Janus Membranes for Efficient Hemostasis

One cannot overstate the advantages of an ideal hemostasis material for the emergency rescue of wars and traffic accident victims, and it can significantly mitigate patient distress and minimize threat to life. Nonetheless, it is still a daunting task to obtain a hemostasis material encompassing desirable advantages, including safety, antibacterial activity, high efficiency, sufficient mechanical strength, cost-effectiveness, and so on. In this study, a one-step electrospinning strategy for achieving an efficient hemostatic membrane with a Janus structure is provided. Owing to the synergistic coagulation effect between gelatin nanofibers and zeolite powders (hydrophilic layer), the membrane exhibits excellent coagulation performance in vitro. Simultaneously, the hydrophobic layer's efficacy in preventing blood permeation further shortens bleeding time and lessens blood loss in vivo. Moreover, the membrane presents commendable flexibility, antibacterial activity, hemocompatibility, and noncytotoxicity, with promise to be used as a safe and efficient hemostatic dressing in clinical applications.