头颈部鳞状细胞癌
免疫系统
生物
癌变
血管生成
癌症研究
肿瘤微环境
细胞
肿瘤科
内科学
免疫学
癌症
医学
头颈部癌
遗传学
作者
Zhonghua Li,Haoxi Cai,Jinyang Zheng,Xun Chen,Guancheng Liu,Yunxia Lv,Hui Ye,Gengming Cai
出处
期刊:Aging
[Impact Journals, LLC]
日期:2023-10-04
卷期号:15 (19): 10347-10369
被引量:2
标识
DOI:10.18632/aging.205081
摘要
Mitochondria play a crucial role in the occurrence and development of tumors. We used mitochondria-related genes for consistent clustering to identify three stable molecular subtypes of head and neck squamous cell carcinoma (HNSCC) with different prognoses, mutations, and immune characteristics. Significant differences were observed in clinical characteristics, immune microenvironment, immune cell infiltration, and immune cell scores. TP53 was the most significantly mutated; cell cycle-related pathways and tumorigenesis-related pathways were activated in different subtypes. Risk modeling was conducted using a multifactor stepwise regression method, and nine genes were identified as mitochondria-related genes affecting prognosis (DKK1, EFNB2, ITGA5, AREG, EPHX3, CHGB, P4HA1, CCND1, and JCHAIN). Risk score calculations revealed significant differences in prognosis, immune cell scores, immune cell infiltration, and responses to conventional chemotherapy drugs. Glycolysis, angiogenesis, hypoxia, and tumor-related pathways were positively correlated with the RiskScore. Clinical samples were subjected to qPCR to validate the results. In this work, we constructed a prognostic model based on the mitochondrial correlation score, which well reflects the risk and positive factors for the prognosis of patients with HNSCC. This model can be used to guide individualized adjuvant and immunotherapy in patients with HNSCC.
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