A Review of Long-acting Parenteral Analgesics for Mice and Rats
医学
重症监护医学
麻醉
药理学
作者
Monika K Huss,Cholawat Pacharinsak
出处
期刊:Journal of The American Association for Laboratory Animal Science [American Association for Laboratory Animal Science] 日期:2022-11-15卷期号:61 (6): 595-602
标识
DOI:10.30802/aalas-jaalas-22-000061
摘要
Appropriate analgesia is a crucial part of rodent postoperative and postprocedural pain. Providing appropriate analgesia is an ethical obligation, a regulatory requirement, and an essential element of obtaining quality scientific results and conducting reproducible data. Meeting these requirements is facilitated by practical, efficient and safe delivery methods for providing analgesia. Over the last decade, long-acting analgesics have gained widespread use in research animal medicine to avoid or treat postoperative or postprocedural pain while minimizing handling-related time and stress. Long-acting formulations of analgesics suitable for rodents are available for opioids, NSAIDs, and local anesthetics. The goal of this review is to summarize the currently available long-acting formulations of analgesics for rodents and to provide recommendations to veterinarians and researchers regarding their use.