特应性皮炎
银屑病
生物标志物
鉴定(生物学)
基因表达
医学
皮肤病科
基因
免疫学
生物
遗传学
植物
作者
Jamie Soul,Enar Carlsson,Sigrun R. Hofmann,S. Russ,J. Hawkes,Felix Schulze,Mildred Sergon,Jessica Pablik,Susanne Abraham,Christian M. Hedrich
标识
DOI:10.1016/j.clim.2024.110283
摘要
Overlapping clinical and pathomechanistic features can complicate the diagnosis and treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis (AD). Spatial transcriptomics allows the identification of disease- and cell-specific molecular signatures that may advance biomarker development and future treatments. This study identified transcriptional signatures in keratinocytes and sub-basal CD4+ and CD8+ T lymphocytes from patients with psoriasis and AD. In silico prediction of ligand:receptor interactions delivered key signalling pathways (interferon, effector T cells, stroma cell and matrix biology, neuronal development, etc.). Targeted validation of selected transcripts, including CCL22, RELB, and JUND, in peripheral blood T cells suggests the chosen approach as a promising tool also in other inflammatory diseases. Psoriasis and AD are characterized by transcriptional dysregulation in T cells and keratinocytes that may be targeted therapeutically. Spatial transcriptomics is a valuable tool in the search for molecular signatures that can be used as biomarkers and/or therapeutic targets.
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