Zr-based multivariate metal-organic framework for rapid extraction of sulfonamide antibiotics from water and food samples

Based on multiple ligands strategy, a series of multivariate metal organic frameworks (MTV-MOFs) named as PCN-224-DCDPSx were prepared using one-pot solvothermal method to extract and remove sulfonamide antibiotics (SAs). The pore structure and adsorption performance can be further regulated by modulating the doping ratios of medium-tetra(4-carboxylphenyl) porphyrin and 4,4'-dicarboxydiphenyl sulfones. The MTV-MOFs of PCN-224-DCDPS1.0 possesses very large specific surface area (1625 m2/g). Using PCN-224-DCDPS1.0 as sorbent, a dispersive solid-phase extraction method was developed to extract and preconcentrate SAs from water, eggs, and milk prior to high performance liquid chromatography analysis. The limits of detection of method were determined between 0.17 and 0.27 ng/mL with enrichment factors ranging 214-327. The adsorption can be finished within 30 seconds, and the recovery rate remains above 80% after 10 repeated uses. The adsorption capacities of sorbent were determined from 300 to 621 mg/g for sulfadiazine, sulphapyridine, sulfamethoxydiazine, sulfachlorpyridazine, sulfabenzamide, and sulfadimethoxine. The adsorption mechanisms were investigated and can be attributed to π-π interactions, hydrogen bonds, and electrostatic interactions. This work represents a method for preparation of MTV-MOFs and uses as sorbent for extraction and enrichment of trace pollutants from complex samples. A great amount of works demonstrated that sulfonamide antibiotics and their metabolites can induce resistance genes in water and have potentially toxic effects on aquatic organisms and humans. Therefore, the removal of sulfonamide antibiotics from environmental water and foods, as well as sensitive detection of them received considerable attention. Herein, a series of multivariate zirconium-based metal organic frameworks MOFs namely PCN-224-DCDPSx were prepared based on multiple ligands strategy and functioned as sorbents to removal and preconcentration of sulfonamide antibiotics. The PCN-224-DCDPS1.0 possessed rapid and excellent adsorption performance for sulfonamide antibiotics.