氨甲环酸
医学
围手术期
加药
血液管理
抗纤维溶解
重症监护医学
血栓形成
麻醉
失血
骨科手术
不利影响
外科
内科学
作者
Prakash A. Patel,Julie Wyrobek,Alexander J. Butwick,Evan G. Pivalizza,Gregory M. T. Hare,C. David Mazer,Susan M. Goobie
标识
DOI:10.1213/ane.0000000000006039
摘要
Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood loss and allogeneic red blood cell transfusion in several clinical settings. With a growing emphasis on patient blood management, TXA has become an integral aspect of perioperative blood conservation strategies. While clinical applications of TXA in the perioperative period are expanding, routine use in select clinical scenarios should be supported by evidence for efficacy. Furthermore, questions regarding optimal dosing without increased risk of adverse events such as thrombosis or seizures should be answered. Therefore, ongoing investigations into TXA utilization in cardiac surgery, obstetrics, acute trauma, orthopedic surgery, neurosurgery, pediatric surgery, and other perioperative settings continue. The aim of this review is to provide an update on the current applications and limitations of TXA use in the perioperative period.
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