化学
二羟基化
亲核细胞
萘
产量(工程)
二醇
催化作用
羟基化
反应机理
反应中间体
立体化学
药物化学
有机化学
酶
对映选择合成
材料科学
冶金
作者
Wenjuan Zhu,Akhilesh Kumar,Jin Xiong,Macon Abernathy,Xiao Xi Li,Mi Sook Seo,Yong Min Lee,Ritimukta Sarangi,Yisong Guo,Wonwoo Nam
摘要
The nature of reactive intermediates and the mechanism of the cis-dihydroxylation of arenes and olefins by Rieske dioxygenases and synthetic nonheme iron catalysts have been the topic of intense research over the past several decades. In this study, we report that a spectroscopically well characterized mononuclear nonheme iron(III)-peroxo complex reacts with olefins and naphthalene derivatives, yielding iron(III) cycloadducts that are isolated and characterized structurally and spectroscopically. Kinetics and product analysis reveal that the nonheme iron(III)-peroxo complex is a nucleophile that reacts with olefins and naphthalenes to yield cis-diol products. The present study reports the first example of the cis-dihydroxylation of substrates by a nonheme iron(III)-peroxo complex that yields cis-diol products.
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