钥匙(锁)
对比度(视觉)
功能(生物学)
锁(火器)
材料科学
对偶(语法数字)
计算机科学
核磁共振
纳米技术
物理
人工智能
工程类
机械工程
操作系统
生物
文学类
艺术
进化生物学
作者
Zhongzhong Lu,Ye Zhang,Mingsheng Xu,Jihuan Liu,Jianxian Zeng,Yu-Xin Ren,Lirong Sun,Ye Zhang,Yi Cao,Renjun Pei
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-07-22
标识
DOI:10.1021/acs.nanolett.4c02669
摘要
Extremely small iron oxide nanoparticle (ESIONP)-based stimuli-responsive switchable MRI contrast agents (CAs) show great promise for accurate detection of tumors due to their outstanding advantages of high specificity and low background signal. However, currently developed ESIONP-based switchable CAs often suffer single-biomarker-induced responses, which lack absolute specificity to pathological tissues, potentially diminishing diagnostic accuracy. In this study, weak acidity and hypoxia, two of the most remarkable characteristics of tumors, are introduced as dual biomarker stimuli to construct an ESIONP-based switchable MRI CA (DKL-CA), with its signal switch controlled by a "dual-key-and-lock" strategy. Only when DKL-CA is exposed to a coexisting weakly acidic and hypoxic environment can monodispersed ESIONPs form nanoclusters, thereby realizing a switch from the T
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