Short‐Peptide‐Induced Diffusion‐limited Plasmonic Aggregation with Broad Spectral Tunability for Wearable Ophthalmic Devices in Color Vision Deficiency Correction

Abstract Smart wearable ophthalmic devices such as contact lenses have gained widespread interest owing to their compactness, portability, and versatility and have emerged as the most promising, non‐invasive, wearable devices for the treatment and diagnosis of a variety of ocular diseases. While contact lenses for the treatment of congenital eye diseases such as color vision deficiency (CVD) are reported, they show limited spectral adjustment range and the unavailability of blocking harmful light such as high‐energy blue light (HEBL). In this study, silver nanoparticle (AgNP) based multifunctional contact lenses that can correct various types of CVDs and filter out harmful light are developed. AgNPs are controllably assembled via short‐peptide‐induced diffusion‐limited aggregation and then integrated into the contact lenses. By varying the sequence and concentration of the peptides, the extinction value of the nanoparticles can be broadly tuned in the 400–600 nm range. The multifunctional contact lenses thus show wide spectral tunability and are capable of efficiently correcting multiple CVDs and blocking HEBL. The contact lenses are found to have excellent biocompatibility with cell and animal tests. In conclusion, the multifunctional contact lenses provide a candidate for the correction of CVD and protection against HEBL, and pave the way for personalized wearable ophthalmic devices.