海湾
胶水
计算机科学
数据科学
医学
材料科学
地质学
海洋学
复合材料
作者
Timothy A. Lewis,Manuel Ellermann,Charlotte Kopitz,Martin Lange,Luc de Waal,Xiaoyun Wu,Adrian Tersteegen,Karsten Denner,Philip Lienau,Stefan Kaulfuß,Silvia Goldoni,Matthew Meyerson,Heidi Greulich,Stefan Gradl
标识
DOI:10.1021/acsmedchemlett.4c00336
摘要
A subset of phosphodiesterase 3 (PDE3) inhibitors kills cancer cells that express both PDE3A and SLFN12 by inducing a protein-protein interaction between the two, triggering SLFN12 tRNase activity. Following discovery of the prototypical tool compound,
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