化学
烷氧基
激进的
氧化磷酸化
叔醇
光化学
有机化学
立体化学
酒
烷基
生物化学
作者
Minsoo Ju,S. Lee,Halle M. Marvich,Song Lin
摘要
Alkoxy radicals are versatile reactive intermediates in organic synthesis. Here, we leverage the principle of frustrated radical pair to provide convenient access to these highly reactive species directly from tertiary alcohols via oxoammonium-mediated oxidation of the corresponding alkoxides. This approach enabled various synthetically useful transformations including β-scission, radical cyclization, and remote C-H functionalization, giving rise to versatile alkoxyamines that can be further elaborated to various functionalities.
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