已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Spike ripples localize the epileptogenic zone best: an international intracranial study

发作性 Spike(软件开发) 涟漪 脑电图 切除术 核医学 听力学 医学 外科 物理 管理 量子力学 电压 精神科 经济
作者
Wen Shi,Dana Shaw,Katherine G. Walsh,Xue Han,Uri T. Eden,R. Mark Richardson,S. Gliske,Julia Jacobs,Benjamin H. Brinkmann,Gregory A. Worrell,William C. Stacey,Birgit Frauscher,John Thomas,Mark Kramer,Catherine J. Chu
出处
期刊:Brain [Oxford University Press]
被引量:11
标识
DOI:10.1093/brain/awae037
摘要

Abstract We evaluated whether spike ripples, the combination of epileptiform spikes and ripples, provide a reliable and improved biomarker for the epileptogenic zone (EZ) compared to other leading interictal biomarkers in a multicenter, international study. We first validated an automated spike ripple detector on intracranial EEG recordings. We then applied this detector to subjects from four centers who subsequently underwent surgical resection with known 1-year outcomes. We evaluated the spike ripple rate in subjects cured after resection (ILAE 1 outcome) and those with persistent seizures (ILAE 2-6) across sites and recording types. We also evaluated available interictal biomarkers: spike, spike-gamma, wideband high frequency oscillation (HFO, 80-500 Hz), ripple (80-250 Hz), and fast ripple (250-500 Hz) rates using previously validated automated detectors. The proportion of resected events was computed and compared across subject outcomes and biomarkers. 109 subjects were included. Most spike ripples were removed in subjects with ILAE 1 outcome (P < 0.001), and this was qualitatively observed across all sites and for depth and subdural electrodes (P < 0.001, P < 0.001). Among ILAE 1 subjects, the mean spike ripple rate was higher in the RV (0.66/min) than in the non-removed tissue (0.08/min, P < 0.001). A higher proportion of spike ripples were removed in subjects with ILAE 1 outcomes compared to ILAE 2-6 outcomes (P = 0.06). Among ILAE 1 subjects, the proportion of spike ripples removed was higher than the proportion of spikes (P < 0.001), spike-gamma (P < 0.001), wideband HFOs (P < 0.001), ripples (P = 0.009) and fast ripples (P = 0.009) removed. At the individual level, more subjects with ILAE 1 outcomes had the majority of spike ripples removed (79%, 38/48) than spikes (69%, P = 0.12), spike-gamma (69%, P = 0.12), wideband HFOs (63%, P = 0.03), ripples (45%, P = 0.01), or fast ripples (36%, P < 0.001) removed. Thus, in this large, multicenter cohort, when surgical resection was successful, the majority of spike ripples were removed. Further, automatically detected spike ripples have improved specificity for epileptogenic tissue compared to spikes, spike-gamma, wideband HFOs, ripples, and fast ripples.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
似水流年发布了新的文献求助10
2秒前
3秒前
4秒前
lin发布了新的文献求助10
7秒前
8秒前
gggghhhh发布了新的文献求助10
9秒前
科目三应助李思言采纳,获得20
13秒前
14秒前
15秒前
北雨发布了新的文献求助10
19秒前
19秒前
MAC发布了新的文献求助10
20秒前
丘比特应助QF采纳,获得10
21秒前
21秒前
22秒前
23秒前
24秒前
岸在海的深处完成签到 ,获得积分10
25秒前
wanci应助失眠的水风采纳,获得10
26秒前
27秒前
nnnd77发布了新的文献求助10
27秒前
暴躁的元灵完成签到 ,获得积分10
30秒前
李思言发布了新的文献求助20
34秒前
似水流年完成签到,获得积分20
35秒前
MillionMiao发布了新的文献求助30
35秒前
36秒前
36秒前
天天快乐应助小方采纳,获得10
38秒前
南宫书瑶发布了新的文献求助10
39秒前
39秒前
lsh发布了新的文献求助10
39秒前
lxy66881完成签到,获得积分10
40秒前
孝顺的尔丝完成签到,获得积分10
40秒前
JamesPei应助piglet采纳,获得10
41秒前
42秒前
43秒前
same发布了新的文献求助10
46秒前
48秒前
上官若男应助El采纳,获得30
49秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 600
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3154722
求助须知:如何正确求助?哪些是违规求助? 2805534
关于积分的说明 7865058
捐赠科研通 2463710
什么是DOI,文献DOI怎么找? 1311554
科研通“疑难数据库(出版商)”最低求助积分说明 629647
版权声明 601832