黄褐斑
酪氨酸酶
氧化应激
超氧化物歧化酶
黑色素
谷胱甘肽过氧化物酶
色素沉着
过氧化氢酶
抗氧化剂
丙二醛
谷胱甘肽
皮肤色素沉着
医学
化学
内科学
内分泌学
皮肤病科
生物化学
酶
作者
Shweta Katiyar,Dhananjay Yadav,Sanjeev K. Singh
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2024-02-01
卷期号:25 (2): 183-188
标识
DOI:10.2174/0113892037269116231115065458
摘要
Background: Melasma, oxidative stress, tyrosinase, antioxidants, Homogenized skin tissues, hyperpigmentation disease. Aims: To compare the levels of oxidative stress and tyrosinase activity in melasma patients with healthy volunteers. Methods: After written consent, 130 patients were enrolled in a case–control study. 65 cases were of melasma disorder, and 65 were served as control. Homogenized skin tissues were taken and used to estimate superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) (antioxidants), malondialdehyde (MDA) and tyrosine hydroxylase (TH). Results: Melasma patients had lower basal levels of systemic antioxidants than healthy subjects. Tyrosinase activity was shown to be greater in lesional skin than in non-lesional skin. In controls, there was a good positive relationship between TH and MDA and an excellent negative relationship between GPx and GSH. In melasma patients, there were significant associations between CAT, GPx, SOD and MDA. Conclusions: Increased oxidative stress may affect tyrosinase activity and eumelanin synthesis via the anabolic pathway of melanin synthesis, according to our findings. In conclusion, we discovered a negative relationship between antioxidants and tyrosinase activity.
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