化学
DNA
致病菌
细菌
编码(内存)
计算生物学
纳米技术
生物系统
遗传学
生物化学
人工智能
材料科学
计算机科学
生物
作者
Mengxue Sun,Hongxia Sun,Chanchan Yu,Peng Lu,Feng Feng,Jin Zhang,Wenchao Li,Li Yao
标识
DOI:10.1021/acs.analchem.4c00298
摘要
Pathogen detection is growing in importance in the early stages of bacterial infection and treatment due to the significant morbidity and mortality associated with bloodstream infections. Although various diagnostic approaches for pathogen detection have been proposed, most of them are time-consuming, with insufficient sensitivity and limited specificity and multiplexing capability for clinical use. Here, we report a force-encoding DNA nanomachine for simultaneous and high-throughput detection of multiple pathogens in blood through force-induced remnant magnetization spectroscopy (FIRMS). The force-encoding DNA nanomachines coupled with DNA walkers enable analytical sensitivity down to a single bacterium via a cascade signal amplification strategy. More importantly, it allows for rapid and specific profiling of various pathogens directly in blood samples, without being affected by factors such as light color and solution properties. We expect that this magnetic sensing platform holds great promise for various applications in biomedical research and clinical diagnostics.
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