生物
体感系统
感觉神经元
感觉系统
神经科学
刺激(心理学)
轴突
背
运动神经元
神经元
解剖
脊髓
心理学
心理治疗师
作者
Lixin Qi,Michael Iskols,David E. Shi,Pranav Reddy,Christopher J. Walker,Karina Lezgiyeva,Tiphaine Voisin,Mathias Pawlak,Vijay K. Kuchroo,Isaac M. Chiu,David D. Ginty,Nikhil Sharma
出处
期刊:Cell
[Elsevier]
日期:2024-03-01
卷期号:187 (6): 1508-1526.e16
被引量:8
标识
DOI:10.1016/j.cell.2024.02.006
摘要
Summary
Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron subtypes relay neural signals from the periphery to the CNS has been challenging with existing tools. Here, we develop and curate a mouse genetic toolkit that allows for interrogating the properties and functions of distinct cutaneous targeting DRG neuron subtypes. These tools have enabled a broad morphological analysis, which revealed distinct cutaneous axon arborization areas and branching patterns of the transcriptionally distinct DRG neuron subtypes. Moreover, in vivo physiological analysis revealed that each subtype has a distinct threshold and range of responses to mechanical and/or thermal stimuli. These findings support a model in which morphologically and physiologically distinct cutaneous DRG sensory neuron subtypes tile mechanical and thermal stimulus space to collectively encode a wide range of natural stimuli.
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