Intrathecal Administration of the Fat-Mass and Obesity-Associated Protein Inhibitor Mitigates Neuropathic Pain in Female Rats

N 6 -methyladenosine (m 6 A) modification of RNA contributes to neuropathic pain genesis by regulating the expression of pain-associated genes in the dorsal root ganglion (DRG) [10][11][12].The fat-mass and obesityassociated protein (FTO), a demethylase, erases m 6 A in mRNA [13].FTO was expressed exclusively in the neurons of DRG [11].The levels of Fto mRNA and FTO protein were time-dependently increased in the injured DRG following peripheral nerve injury [11].Blocking this increase through DRG microinjection of Fto siRNA or AAV5 expressing the FTO-specific guide RNA in male rats or DRG microinjection of AAV5 expressing Cre in male Fto fl/fl mice reversed a loss of m 6 A sites in euchromatic