已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Characterizing the distribution of alterations in mesothelioma and their correlation to morphology

间皮瘤 BAP1型 腹膜 病理 医学 CDKN2A 上皮样细胞 免疫组织化学 内科学 癌症
作者
Heather I-Hsuan Chen-Yost,Melissa Y. Tjota,Guimin Gao,Owen Mitchell,Hedy L. Kindler,Jeremy P. Segal,Aliya N. Husain,Jeffrey Mueller,Jefree J. Schulte
出处
期刊:American Journal of Clinical Pathology [Oxford University Press]
卷期号:160 (3): 238-246
标识
DOI:10.1093/ajcp/aqad041
摘要

Abstract Objectives Mesothelioma is a lethal disease that arises from the serosal lining of organ cavities. Several recurrent alterations have been observed in pleural and peritoneal ­mesotheliomas, including in BAP1, NF2, and CDKN2A. Although specific histopathologic parameters have been correlated with prognosis, it is not as well known whether genetic alterations correlate with histologic findings. Methods We reviewed 131 mesotheliomas that had undergone next-generation sequencing (NGS) at our institutions after pathologic diagnosis. There were 109 epithelioid mesotheliomas, 18 biphasic mesotheliomas, and 4 sarcomatoid mesotheliomas. All our biphasic and sarcomatoid cases arose in the pleura. Of the epithelioid mesotheliomas, 73 were from the pleura and 36 were from the peritoneum. On average, patients were 66 years of age (range, 26-90 years) and predominantly male (92 men, 39 women). Results The most common alterations identified were in BAP1, CDKN2A, NF2, and TP53. Twelve mesotheliomas did not show a pathogenic alteration on NGS. For epithelioid mesotheliomas in the pleura, the presence of an alteration in BAP1 correlated with low nuclear grade (P = .04), but no correlation was found in the peritoneum (P = .62). Similarly, there was no correlation between the amount of solid architecture in epithelioid mesotheliomas and any alterations in the pleura (P = .55) or peritoneum (P = .13). For biphasic mesotheliomas, cases with either no alteration detected or with an alteration in BAP1 were more likely to be epithelioid predominant (>50% of the tumor, P = .0001), and biphasic mesotheliomas with other alterations detected and no alteration in BAP1 were more likely to be sarcomatoid predominant (>50% of the tumor, P = .0001). Conclusions This study demonstrates a significant association between morphologic features associated with a better prognosis and an alteration in BAP1.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Jayden完成签到,获得积分10
3秒前
3秒前
4秒前
香蕉觅云应助痴情的绮菱采纳,获得10
4秒前
Ava应助RW采纳,获得10
5秒前
Christoph_Lee发布了新的文献求助10
6秒前
NPC-CBI发布了新的文献求助30
9秒前
愫浅发布了新的文献求助10
10秒前
研友_VZG7GZ应助Jayden采纳,获得20
10秒前
大大小完成签到,获得积分0
12秒前
七月流火应助Liam采纳,获得30
12秒前
14秒前
情怀应助愫浅采纳,获得10
17秒前
赘婿应助Ericlee采纳,获得10
19秒前
xiaohu发布了新的文献求助10
19秒前
桐桐应助饭团不吃鱼采纳,获得10
21秒前
善学以致用应助meme采纳,获得10
22秒前
嗯哼应助heart采纳,获得30
24秒前
Ericlee完成签到,获得积分20
26秒前
勇敢飞的xf完成签到,获得积分10
27秒前
大力的月光完成签到,获得积分10
27秒前
28秒前
29秒前
weiboo完成签到,获得积分10
30秒前
坤的信徒完成签到,获得积分10
30秒前
英俊的铭应助zzzzz采纳,获得50
30秒前
32秒前
33秒前
香蕉觅云应助capitalist采纳,获得10
34秒前
meme发布了新的文献求助10
35秒前
umil发布了新的文献求助10
35秒前
星空完成签到,获得积分10
38秒前
38秒前
咖咖咖喱完成签到,获得积分10
39秒前
坤的信徒发布了新的文献求助10
41秒前
43秒前
Christoph_Lee完成签到,获得积分10
43秒前
44秒前
潇洒的竹杖完成签到,获得积分10
44秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248513
求助须知:如何正确求助?哪些是违规求助? 2891915
关于积分的说明 8269223
捐赠科研通 2559929
什么是DOI,文献DOI怎么找? 1388807
科研通“疑难数据库(出版商)”最低求助积分说明 650897
邀请新用户注册赠送积分活动 627798