违反直觉
基因调控网络
过程(计算)
托换
生物
计算生物学
系统生物学
钥匙(锁)
计算机科学
基因
基因表达
遗传学
工程类
生态学
认识论
操作系统
哲学
土木工程
作者
M. Joaquina Delás,James Briscoe
出处
期刊:Current Topics in Developmental Biology
日期:2020-01-01
卷期号:: 239-266
被引量:28
标识
DOI:10.1016/bs.ctdb.2020.03.003
摘要
Tightly regulated gene expression programs, orchestrated by complex interactions between transcription factors, control cell type specification during development. Repressive interactions play a critical role in these networks, facilitating decision-making between two or more alternative cell fates. Here, we use the ventral neural tube as an example to illustrate how cross repressive interactions within a network drive pattern formation and specify cell types in response to a graded patterning signal. This and other systems serve to highlight how external signals are integrated through the cis regulatory elements controlling key genes and provide insight into the molecular underpinning of the process. Even the simplest networks can lead to counterintuitive results and we argue that a combination of experimental dissection and modeling approaches will be necessary to fully understand network behavior and the underlying design principles. Studying these gene regulatory networks as a whole ultimately allows us to extract fundamental properties applicable across systems that can expand our mechanistic understanding of how organisms develop.
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