Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher

伤口愈合 肉芽组织 壳聚糖 生物相容性 造粒 材料科学 肿胀 的 生物医学工程 多糖 化学 医学 复合材料 外科 生物化学 冶金
作者
Mingjun Yang,Run Li,Xinjian Wang,Xiaofeng Liu,Baigang Zhang,Yonggang Wang
出处
期刊:Biomedical Materials [IOP Publishing]
卷期号:16 (2): 025015-025015 被引量:14
标识
DOI:10.1088/1748-605x/abd051
摘要

Abstract Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides could promote vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract of Nostoc commune Vaucher polysaccharides (UAP) yield after the process optimization was 12.89 ± 0.24%, which was used to prepare microcapsules by emulsification and cross-linking. The effect of alginate/chitosan-UAP composite materials on wound healing in an experimental rat model for 14 d and its physical properties were evaluated. In vitro experiments indicated that the UAP microcapsule material had a porous and loose three-dimensional network structure, and had good biocompatibility and swelling properties as a wound healing material. Animal experiments indicated that UAP microcapsules could extremely significantly promote wound healing ( P < 0.01), and wound closure rate reached 79.16 ± 3.91% on 14th day. Meanwhile UAP microcapsules might promote angiogenesis and granulation growth by enhancing immunity and increasing the expression of VEGF and miR-21. Therefore, the composites of UAP microcapsules have shown encouraging results as a potential dressing for wound healing.
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