医学
糖尿病
有机磷
胰岛素抵抗
2型糖尿病
胰岛素
2型糖尿病
机制(生物学)
内科学
重症监护医学
杀虫剂
内分泌学
生物
农学
认识论
哲学
作者
JDhivya lakshmi,Krishnendu Mukhopadhyay,Kalpana Balakrishnan,Shriraam Mahadevan
出处
期刊:Current Diabetes Reviews
[Bentham Science]
日期:2019-09-11
卷期号:16 (6): 586-597
被引量:12
标识
DOI:10.2174/1573399815666190712192844
摘要
Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose breakdown in numerous and mechanism. There are higher evidence of stimulating diabetes mellitus through OP pesticides especially the type II diabetes. The upsurge in the level of glucose (hyperglycemia), and insulin resistance along with their related outcomes are discussed in this review. The data related to investigational and clinical techniques endorse a connection amid such molecular mechanism and compounds of OPs. Numerous studies conducted till March 2018 have reported OP’ exposures and diabetes-related outcomes. The acute and chronic exposure in case of these insecticides and diabetesrelated outcomes are defined in this study. Initially, it was declared that OPs prompt to hyperglycemia. Then, a high association of glucose in blood beside insulin was found out. The affirmation from some clinical as well as investigational studies supported a connection amid exposure to OP and diabetes, yet in maximum number of instances, non-specific diabetes occurs.
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