Design, synthesis, and anticancer activities of sodium quinazolin‐4‐diselenide compounds

Abstract Substituted 4‐chloroquinazoline reacted with sodium diselenide to give novel sodium quinazoline‐4‐diselenide compounds. The reaction provides an efficient and facile approach to the synthesis of sodium quinazoline‐4‐diselenide compounds. Structures of title compounds were confirmed by IR, 1 H NMR, 13 C NMR, and elemental analysis. MTT assay was adopted to show anticancer activities of the compounds. Compounds 5a and 5h showed good activities against cancer‐cell lines MDA‐MB‐435, MDA‐MB‐231, A549, SiHa, and HeLa. In addition, 5a exhibited quite good anticancer effects on relative above cell lines with 10μ M concentration compared with oxaliplatin and gefitinib of the commercial anticancer drugs.