医学
CD19
CD20
B细胞
糖皮质激素
IgG4相关疾病
记忆B细胞
免疫学
美罗华
流式细胞术
发病机制
等离子体电池
强的松
内科学
抗体
疾病
作者
Marco Lanzillotta,Emanuel Della‐Torre,Raffaella Milani,Enrica Bozzolo,Emanuele Bozzalla-Cassione,Lucrezia Rovati,Paolo Giorgio Arcidiacono,Stefano Partelli,Massimo Falconi,Fabio Ciceri,Lorenzo Dagna
出处
期刊:PubMed
日期:2019-01-18
卷期号:37 Suppl 118 (3): 159-166
被引量:7
摘要
Glucocorticoids induce prompt clinical improvement in patients with IgG4-related disease (IgG4-RD) but their mechanisms of action in this specific condition are not fully understood. B lymphocytes appear central to IgG4-RD pathogenesis because B-cell depletion with rituximab leads to swift clinical responses. In the present work we aim to assess the effects of glucocorticoids on B-cell subpopulations in patients with IgG4-RD.Fifty patients with active untreated IgG4-RD and 20 healthy controls were enrolled in the present study. Flow cytometry analysis for total circulating CD19+ and CD20+ cells, naïve B cells, memory B cells, plasmablasts, and plasma cells was performed at baseline in all patients, and after 6 months of glucocorticoid treatment in 30 patients. Correlation studies with biomarkers of disease activity were also performed.At baseline, patients with IgG4-RD showed reduced CD19+ and CD20+ B cells compared to healthy controls, but increased circulating plasmablasts and plasma cells. Circulating plasmablasts and plasma cells correlated with clinical and serological biomarkers of IgG4-RD activity. Glucocorticoid-induced disease remission was accompanied by a reduction of naïve B cell count, an increase of memory B cells, and by a depletion of circulating plasmablasts and plasma cells. CD19+ and CD20+ B cells, were not affected by glucocorticoids.The efficacy of glucocorticoids in IgG4-RD is associated with selective effects on different B-cell subpopulations. Further studies are warranted to fully understand possible perturbations of the naïve and memory B-cell compartments in patients with IgG4-RD.
科研通智能强力驱动
Strongly Powered by AbleSci AI