Cyclotron production of 101Pd/101mRh radionuclide generator for radioimmunotherapy

Abstract 101m Rh is one of such radionuclides that has been considered as a potential candidate for targeted radiotherapeutic use, due to its nuclear decay and chemical properties. Electrodeposition of rhodium metal on a copper backing was performed in acidic sulphate. The target was bombarded with a current intensity of 120 μA (E p = 29 → 25 MeV) for 30 min (60 μAh). Radiochemical methods were investigated to optimize the production of no-carrier-added 101 Pd/ 101m Rh. The use of a cyclotron target with radiochemical processes (i.e. electrodeposition, electrodissolution and ion-exchange column chromatography) were carried out to produce this radionuclide in high-specific activity and radiochemical form suitable for radiopharmaceutical syntheses.