Terminology of nodular hepatocellular lesions

HepatologyVolume 22, Issue 3 p. 983-993 Special ArticleFree Access Terminology of nodular hepatocellular lesions Ian R. Wanless MD, Corresponding Author Ian R. Wanless MD Department of Pathology, The Toronto Hospital, 200 Elizabeth St, Toronto, Canada, M5G 2C4Department of Pathology, The Toronto Hospital, 200 Elizabeth St, Toronto, Canada, M5G 2C4===Search for more papers by this authorInternational Working Party, International Working PartySearch for more papers by this author Ian R. Wanless MD, Corresponding Author Ian R. Wanless MD Department of Pathology, The Toronto Hospital, 200 Elizabeth St, Toronto, Canada, M5G 2C4Department of Pathology, The Toronto Hospital, 200 Elizabeth St, Toronto, Canada, M5G 2C4===Search for more papers by this authorInternational Working Party, International Working PartySearch for more papers by this author First published: September 1995 https://doi.org/10.1002/hep.1840220341Citations: 877AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Anthony PP, Ishak KG, Nayak NC, Poulsen HE, Scheuer PJ, Sobin LH. The morphology of cirrhosis: recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol 1978; 31: 395– 414. 2 Craig JR, Peters RL, Edmondson HA. Tumors of the liver and intrahepatic bile ducts. (Fascicle 26, 2nd series). Washington, DC: Armed Forces Institute of Pathology, 1989. 3 Crawford JM. Pathologic assessment of liver cell dysplasia and benign liver tumors: differentiation from malignant tumors. Semin Diagn Pathol 1990; 7: 115– 128. 4 Ferrell LD, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y. Proposal for standardized criteria for the diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver disease. Am J Surg Pathol 1993; 17: 1113– 1123. 5 Ishak KG, Anthony PP, Sobin LH. Histological typing of tumours of the liver. Ed 2. Berlin, Springer-Verlag, 1994. 6 Nakanuma Y, Terada T, Ueda K, Terasaki S, Nonomura A, Matsui O. Adenomatous hyperplasia of the liver as a precancerous lesion. Liver 1993; 13: 1– 9. 7 Okuda K, Ishak KG. Neoplasms of the liver. Tokyo: Springer-Verlag, 1987. 8 RA Coté, DJ Rothwell, JL Palotay, et al, eds. SNOMED International [Systematized Nomenclature of Human and Veterinary Medicine]. Ed 3, Vols I and II, Numeric indices; Vol III and IV, Alphabetic indices. Chicago: College of American Pathologists, 1993. 9 Wada K, Kondo F, Kondo Y. Large regenerative nodules and dysplastic nodules in cirrhotic livers: a histopathologic study. Hepatology 1988; 8: 1684– 1688. 10 Wanless IR. Vascular disorders. In: RNM MacSween et al, eds. Pathology of the liver. Ed 3. Edinburgh: Churchill Livingstone, 1994: 535– 562. 11 Weinberg AG, Finegold MJ. Primary hepatic tumors of childhood. Hum Pathol 1983; 14: 512– 537. 12 Wanless IR. Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 1990; 11: 787– 797. 13 Castellano G, Canga F, Solis-Herruzo JA, Colina F, Martinez-Montiel MP, Morillas JD. Budd-Chiari syndrome associated with nodular regenerative hyperplasia of the liver. J Clin Gastroenterol 1989; 11: 698– 702. 14 de Sousa JMM, Portmann B, Williams R. Nodular regenerative hyperplasia of the liver and the Budd-Chiari syndrome: case report, review of the literature and reappraisal of pathogenesis. J Hepatol 1991; 12: 28– 35. 15 Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology 1985; 5: 1194– 1200. 16 Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973; 26: 217– 223. 17 Anthony PP. Liver cell dysplasia: what is its significance? Hepatology 1987; 7: 394– 395. 18 Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, Takahashi T. Morphologic studies of the liver cell dysplasia. Cancer 1983; 51: 2197– 2205. 19 Cohen C, Berson SD. Liver cell dysplasia in normal, cirrhotic and hepatocellular carcinoma patients. Cancer 1986; 57: 1535– 1538. 20 Lefkowitch J, Apfelbaum TF. Liver cell dysplasia and hepatocellular carcinoma in non-A, non-B hepatitis. Arch Pathol Lab Med 1987; 111: 170– 173. 21 Roncalli M, Borzio M, Tombesi MV, Ferrari A, Servida E. A morphometric study of liver cell dysplasia. Hum Pathol 1988; 19: 471– 474. 22 Nakanuma Y, Kanel GC, Moishita K, Ohta G, Peters RL. Risk lesions in cirrhosis and development of hepatocellular carcinoma: an autopsy study. Biomed Pharmacother 1989; 43: 127– 133. 23 Weinbren K, Mutum SS. Pathological aspects of diffuse nodular hyperplasia of the liver. J Pathol 1984; 143: 81– 92. 24 Steiner PE. Nodular regenerative hyperplasia of the liver. Am J Pathol 1959; 35: 943– 953. 25 Stromeyer FW, Ishak KG. Nodular transformation (nodular “regenerative” hyperplasia) of the liver. Hum Pathol 1981; 12: 60– 71. 26 Wanless IR. Portal vein thrombosis is associated with large regenerative nodules and diffuse nodular hyperplasia in cirrhotic livers. Hepatology 1994; 20: 412A. 27 Eguchi A, Nakashima O, Okudaira S, Sugihara S, Kojiro M. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992; 15: 843– 848. 28 Hadjis NS, Blumgart LH. Clinical aspects of liver atrophy. J Clin Gastroenterol 1989; 11: 3– 7. 29 Tavill AS, Wood EJ, Creel L, Jones EA, Gregory M, Sherlock S. The Budd-Chiari syndrome: correlation between hepatic scintigraphy and the clinical, radiological and pathological findings in 19 cases of hepatic venous outflow obstruction. Gastroenterology 1975; 68: 509– 518. 30 Wanless IR, Albrecht S, Bilbao J, Frei JV, Heathcote EJ, Roberts EA, Chiasson D. Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome. Mod Pathol 1989; 2: 456– 462. 31 Wanless IR, Gryfe A. Nodular transformation of the liver in hereditary hemorrhagic telangiectasia. Arch Pathol Lab Med 1986; 110: 331– 335. 32 Ndimbie OK, Goodman ZD, Chase RL, Ma CK, Lee MW. Hemangiomas with localized nodular proliferation of the liver: a suggestion on the pathogenesis of focal nodular hyperplasia. Am J Surg Pathol 1990; 14: 142– 150. 33 Lui AFK, Hiratzka LF, Hirose FM. Multiple adenomas of the liver. Cancer 1980; 45: 1001– 1004. 34 Flejou JF, Barge J, Menu Y, Degott C, Bismuth H, Potet F, Benhamou JP. Liver adenomatosis: an entity distinct from liver adenoma? Gastroenterology 1985; 89: 1132– 1138. 35 Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: observations in 5 cases. Gastroenterology 1986; 91: 198– 208. 36 Ferrell L, Wright T, Lake J, Roberts J, Ascher N. Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. Hepatology 1992; 16: 1372– 1381. 37 Furuya K, Nakamura M, Yamamoto Y, Togei K, Otsuka H. Macroregenerative nodule of the liver: a clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 1988; 61: 99– 105. 38 Terada T, Terasaki S, Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 1993; 72: 1551– 1556. 39 Nagato Y, Kondo F, Kondo Y, Ebara M, Ohto M. Histological and morphometrical indicators for a biopsy diagnosis of welldifferentiated hepatocellular carcinoma. Hepatology 1991; 14: 473– 478. 40 Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991; 22: 172– 178. 41 Sugihara S, Nakashima O, Kojiro M, Majima Y, Tanaka M, Tanikawa K. The morphologic transition in hepatocellular carcinoma: a comparison of the individual histologic features disclosed by ultrasound-guided fine-needle biopsy with those of autopsy. Cancer 1992; 70: 1488– 1492. 42 Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, Kosuge T, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990; 336: 1150– 1153. 43 Theise ND, Schwartz M, Miller C, Thung SN. Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 1992; 16: 949– 955. 44 Terada T, Ueda K, Nakanuma Y. Histopathological and morphometric analysis of atypical adenomatous hyperplasia of human cirrhotic livers. Virchows Arch A Pathol Anat 1993; 422: 381– 388. 45 Deugnier YM, Charalambous P, Le Quilleuc D, Turlin B, Searle J, Brissot P, Powell LW, et al. Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: a study of 185 patients. Hepatology 1993; 18: 1363– 1369. 46 Hsu HC, Chiou TJ, Chen JY, Lee CS, Lee PH, Peng SY. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 1991; 13: 923– 928. 47 Tsuda H, Hirohashi S, Shimosato Y, Terada M, Hasegawa H. Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma. Gastroenterology 1988; 95: 1664– 1666. 48 Zhang X, Huang D, Qui D-K, Chiu J. The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors. Oncogene 1990; 5: 909– 914. 49 Kondo F, Kondo Y, Nagato Y, Tomizawa M, Wada K. Interstitial tumor cell invasion in small hepatocellular carcinoma: evaluation in microscopic and low magnification views. J Gastroenterol Hepatol 1994; 9: 604– 612. 50 Nakano M, Saito A, Takasaki K, Obata H, Kobayashi S. A histopathologic study of early hepatocellular carcinoma: Portal tract invasion and progression to advanced hepatocellular carcinoma. Acta Hepatol Japan 1990; 31: 754– 762. 51 Nagao T, Kondo F, Sato T, Nagato Y, Kondo Y. Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: correlation with cell proliferative activity indices including mitotic index and MIB-1 immunostaining. Hum Pathol 1995; 26: 326– 333. Citing Literature Volume22, Issue3September 1995Pages 983-993 ReferencesRelatedInformation