Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

医学 乳腺癌 糖尿病 荟萃分析 危险系数 内科学 癌症 肿瘤科 人口 死因 梅德林 疾病 置信区间 内分泌学 法学 环境卫生 政治学
作者
Kimberly S. Peairs,Bethany B Barone,Claire Snyder,Hsin-Chieh Yeh,Kelly B. Stein,Rachel Derr,Frederick L. Brancati,Antonio C. Wolff
出处
期刊:Journal of Clinical Oncology [Lippincott Williams & Wilkins]
卷期号:29 (1): 40-46 被引量:378
标识
DOI:10.1200/jco.2009.27.3011
摘要

Purpose The goal of this study was to perform a systematic review and meta-analysis to examine the effect of pre-existing diabetes on breast cancer–related outcomes. Methods We searched EMBASE and MEDLINE databases from inception through July 1, 2009, using search terms related to diabetes mellitus, cancer, and prognostic outcome. Studies were included if they reported a prognostic outcome by diabetes status, evaluated a cancer population, and contained original data published in the English language. We performed a meta-analysis of pre-existing diabetes and its effect on all-cause mortality in patients with breast cancer and qualitatively summarized other prognostic outcomes. Results Of 8,828 titles identified, eight articles met inclusion/exclusion criteria and described outcomes in patients with breast cancer and diabetes. Pre-existing diabetes was significantly associated with all-cause mortality in six of seven studies. In a meta-analysis, patients with breast cancer and diabetes had a significantly higher all-cause mortality risk (pooled hazard ratio [HR], 1.49; 95% CI, 1.35 to 1.65) compared with their nondiabetic counterparts. Three of four studies found pre-existing diabetes to be associated with more advanced stage at presentation. Diabetes was also associated with altered regimens for breast cancer treatment and increased toxicity from chemotherapy. Conclusion Compared with their nondiabetic counterparts, patients with breast cancer and pre-existing diabetes have a greater risk of death and tend to present at later stages and receive altered treatment regimens. Studies are needed to investigate pathophysiologic interactions between diabetes and breast cancer and determine whether improvements in diabetes care can reduce mortality in patients with breast cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Qi完成签到 ,获得积分10
刚刚
百事可乐完成签到 ,获得积分10
2秒前
李嘉欣发布了新的文献求助10
2秒前
小万完成签到,获得积分10
3秒前
Lucas应助开灯人和关灯人采纳,获得10
3秒前
怕孤独的冰淇淋完成签到,获得积分10
4秒前
禹与于发布了新的文献求助10
5秒前
persist发布了新的文献求助10
5秒前
向上发布了新的文献求助10
6秒前
量子星尘发布了新的文献求助10
6秒前
111完成签到,获得积分10
6秒前
7秒前
Heartlark完成签到,获得积分10
9秒前
11秒前
罗拉发布了新的文献求助10
11秒前
斯文懿轩完成签到 ,获得积分10
14秒前
向上完成签到,获得积分10
14秒前
旺仔牛奶糖完成签到,获得积分10
14秒前
顾矜应助卖萌的秋田采纳,获得10
14秒前
14秒前
糊涂的不尤完成签到 ,获得积分10
15秒前
15秒前
16秒前
Zzzzzzz完成签到 ,获得积分10
17秒前
bkagyin应助火星上的百川采纳,获得10
17秒前
yexu845发布了新的文献求助150
18秒前
20秒前
爱笑晓曼给爱笑晓曼的求助进行了留言
20秒前
木木应助禹与于采纳,获得20
22秒前
风雪丽人完成签到,获得积分10
23秒前
STZHEN完成签到,获得积分10
24秒前
26秒前
忆修完成签到,获得积分10
26秒前
星辰大海应助谢琉圭采纳,获得10
27秒前
yexu845完成签到,获得积分10
28秒前
不能吃了发布了新的文献求助10
29秒前
科研通AI2S应助明天见采纳,获得10
29秒前
32秒前
34秒前
水溶c100发布了新的文献求助10
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173