药物输送
电子顺磁共振
纳米载体
药品
高分子
化学
小分子
药理学
毒品携带者
生物物理学
纳米技术
医学
材料科学
生物化学
生物
核磁共振
有机化学
物理
标识
DOI:10.1016/j.addr.2010.03.011
摘要
Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI