双氯芬酸钠
美洛昔康
双氯芬酸
医学
丙二醛
组织病理学
超氧化物歧化酶
骨愈合
肾
药理学
麻醉
外科
内科学
病理
氧化应激
作者
Sermet İnal,Şahin Kabay,Muhammet Kasım Çaycı,Halil İsa Kuru,Sayit Altıkat,Gizem Akkaş,Ayşenur Deger
标识
DOI:10.1016/j.injury.2013.10.002
摘要
Objectives Nonsteroidal anti-inflammatory drugs (NSAIDs) are particularly used in patients with bone fractures, but there are limited studies on whether one NSAID is superior to another. In this study, we used histopathological and biochemical parameters to determine whether there are differences between the effects of the administration of clinical doses of dexketoprofen trometamol (DEXT), meloxicam (MEL) and diclofenac sodium (DIC) on the healing of closed fibular fractures and the toxicity of both the liver and kidney. Methods Twenty-eight male Sprague-Dawley rats were randomly divided into four groups of seven each. Closed diaphyseal fractures were formed in the left fibulas of all of the rats. The NSAIDs dexketoprofen trometamol (DEXT) (Arveles®), meloxicam (MEL) (Melox®) and diclofenac sodium (DIC) (Voltaren®) were intramuscularly administered to Groups I, II, and III, respectively, for a period of 10 days after the fibular fractures were performed. No pharmacological agents were administered to Group IV (Control group). Blood samples were collected from all of the rats after the fractures were performed, and the rats were sacrificed on day 28. The histopathological findings were compared, and the blood samples were evaluated to determine any differences between the levels of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA). Results Our results suggest that DEXT and MEL impair the healing of bone fractures and that DIC does not histopathologically affect the healing process of bone fractures. We also found that DEXT, MEL, and DIC impaired the renal histopathology compared with the control group. However, the liver histopathological analysis showed that DEXT and MEL caused a higher degree of parenchymal necrosis compared with DIC. Conclusion Based on our results, DIC can be considered a relatively safe medication in patients with fractures.
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