Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats

阿斯巴甜 情绪性 糖精 开阔地 焦虑 内科学 摄入 内分泌学 药理学 化学 心理学 医学 发展心理学 生物化学 精神科
作者
Ashok Iyaswamy,Rathinasamy Sheeladevi,Dapkupar Wankhar
出处
期刊:Biomedicine & Preventive Nutrition [Elsevier]
卷期号:4 (1): 39-43 被引量:25
标识
DOI:10.1016/j.bionut.2013.04.002
摘要

The focus of the study is to investigate whether the long-term (90 days) oral administration of aspartame (75 mg/kg) has an effect in the anxiety, locomotor activity and emotionality behavior of Wistar strain male Albino rats. Aspartame releases methanol as one of its metabolites during metabolism. To mimic the human methanol metabolism, the methotrexate (MTX)-treated folate-deficient rats were used. Aspartame was administered orally to the MTX-treated animals and was studied along with controls and MTX-treated controls. The locomotor activity and emotionality behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked increase in the immobilization, fecal bolus with a marked decrease in ambulation (peripheral square and central square), rearing, grooming from the control as well the MTX-treated animals. The anxiety state behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked decrease in the number of open arm entry, percentage of open arm entry, time spent in open arm, percentage of time spent in open arm and number of head dips from the control as well the MTX-treated animals. It is relevant to point out that methanol released by aspartame may add an effect in the brain and that could be the additional contributing factor for the observed changes in the locomotor and their anxiety levels. This study intends to substantiate that long-term aspartame consumption can alter the behavior.
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