小胶质细胞
发病机制
免疫系统
炎症
先天免疫系统
免疫学
神经炎症
医学
疾病
阿尔茨海默病
痴呆
免疫疗法
神经科学
生物
病理
作者
María Serpente,R Bonsi,Elio Scarpini,Daniela Galimberti
出处
期刊:Neuroimmunomodulation
[S. Karger AG]
日期:2014-01-01
卷期号:21 (2-3): 79-87
被引量:76
摘要
Immune activation and inflammation, likely triggered by amyloid-beta (Aβ) deposition, play a remarkable role in the pathogenesis of Alzheimer's disease (AD), which is the most frequent cause of dementia in the elderly. The principal cellular elements of the brain innate immune system likely to be involved in such processes are microglia. In an attempt to search for new disease-modifying drugs, the immune system has been addressed, with the aim of removing deposition of Aβ or tau by developing vaccines and humanized monoclonal antibodies. The aim of this review is to summarize the current evidence regarding the role played by microglia and inflammatory molecules in the pathogenesis of AD. In addition, we will discuss the main active and passive immunotherapeutic approaches.
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