Genetic variant of TMBIM1 is associated with the susceptibility of colorectal cancer in the Chinese population

结直肠癌 基因型 医学 等位基因 转移 内科学 肿瘤科 等位基因频率 人口 淋巴结转移 癌症 胃肠病学 基因 遗传学 生物 环境卫生
作者
Jie Zhang,Yiwei Fu,Jiebin Chen,Qianjun Li,Huimin Guo,Bin Yang
出处
期刊:Clinics and Research in Hepatology and Gastroenterology [Elsevier BV]
卷期号:43 (3): 324-329 被引量:5
标识
DOI:10.1016/j.clinre.2018.10.013
摘要

Recent meta-analysis of genome-wide association studies (GWASs) identified a novel variant rs992157 at 2q35 that was associated with colorectal cancer (CRC) in the population of European ancestry. We aimed to replicate the association of rs992157 with CRC in the Chinese population and to further determine the real susceptible gene of CRC as indicated by this variant. 824 CRC patients and 1063 healthy controls were included. The frequency of the genotype and the allele of rs992157 were compared between the patients and the controls and between different subgroups of patients classified by status of metastasis. Expression level of TMBIM1 was compared between the tumor tissue and the adjacent normal tissues collected from 43 patients during surgery. Besides, the relationship between genotypes of rs992157 and the tissue expression of TMBIM1 was analyzed. Patients were found to have significantly higher frequency of allele G than the controls (44.2% vs. 40.0%, P = 0.009; OR = 1.18). Moreover, allele G was associated with an increased risk of lymph node metastasis (P = 0.02) and distant metastasis of CRC (P = 0.04). The mean expression level of TMBIM1 was significantly higher in tumor tissue than in the adjacent normal tissues (0.0019 ± 0.00068 vs. 0.00041 ± 0.00024, P < 0.001). In addition, patients with genotype GG were found to have remarkably higher TMBIM1 expression in the tumors than those with genotype AA (0.0024 ± 0.00052 vs. 0.0015 ± 0.00078, P = 0.005). Variant rs992157 is significantly associated with the susceptibility and progression of CRC. It can increase the risk of CRC possibly via up-regulation of TMBIM1.
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