脂蛋白(a)
载脂蛋白B
脂蛋白
内科学
外围设备
心脏病学
血浆脂蛋白
医学
颈动脉
风险因素
胆固醇
冠状动脉粥样硬化
冠心病
内分泌学
作者
Narek A. Tmoyan,O. Afanasieva,М. В. Ежов
出处
期刊:Kardiologiya
[APO Society of Specialists in Heart Failure]
日期:2018-01-01
卷期号:17 (6): 70-78
被引量:3
标识
DOI:10.18087/cardio.2018.6.10135
摘要
Lipoprotein(a) [Lp(a)] consists of an LDL-like particle in which the apolipoprotein B100 is covalently bound to apolipoprotein(a) by a single disulfide bond. Lp(a) is synthesized in the liver and its plasma concentration varies from 0 to 400 mg/dl. Increased level of Lp(a) is considered to be an independent risk factor of cardiovascular diseases and coronary heart disease. Data about the significance of hyperlipoproteinemia(a) in the development of atherosclerosis of peripheral (lower limbs) and carotid arteries remain controversial. This review is devoted to Lp(a), its relationship with atherosclerosis of different vascular beds, as well as modern possibilities of hyperlipoproteinemia(a) correction.
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