Dramatic but suspensive effect of interleukin-1 inhibitors for persistent urticarial vasculitis: a French multicentre retrospective study

Urticarial vasculitis (UV) is rare systemic disease characterised by a dermal capillary inflammation responsible of long-lasting urticarial lesions, and sometimes some systemic manifestations.1 2 UV can be separated into two different entities: hypocomplementemic UV (HUV) and normocomplementemic UV (NUV). Treatment of UV depends on the severity of the disease and the occurrence of relapses. In patients refractory to colchicine or dapsone, glucocorticoids (GCs), conventional immunosuppressive agents or rituximab (RTX) can be used,1 2 leading to significant morbidity. Interleukin-1β (IL-1β) inhibitors are biologics mainly used in autoinflammatory diseases.3 We report here a French retrospective multicentr study of patients treated with IL-1β inhibitors for persistent disease despite GCs and/or immunosuppressive agents. This French retrospective multicentre study was conducted in four departments of Dermatology and Internal Medicine. We included patients with persistent UV to at …