An Efficient Way to Synthesize N-(β-Nitroalkyl) Amides through Ritter Reaction

An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through Ritter reaction and the yield is up to 95%. Keywords: Alcohols, amides, carbocation, catalysis, nitriles.