神经科学
皮质脊髓束
神经可塑性
运动皮层
长时程增强
锥体束
脊髓
初级运动皮层
磁刺激
可塑性
突触可塑性
脊髓损伤
运动学习
轴突
皮质(解剖学)
心理学
作者
Alzahraa Amer,Jianxun Xia,Michael Thomas Smith,John H. Martin
标识
DOI:10.1073/pnas.2113192118
摘要
Significance The motor cortex (MCX) and corticospinal tract are necessary for producing skilled movements. Whereas much is known about MCX plasticity and its role in acquiring and maintaining motor skills, much less is known about spinal circuit contributions. We investigate a spinal locus for corticospinal tract plasticity in anesthetized rats. We identify long-term potentiation (LTP) of the corticospinal tract monosynaptic excitatory synapse with spinal interneurons, as well as LTP of an oligosynaptic response in the wrist motor pool. Our findings are important for understanding the key structures for motor learning and motor recovery after injury and suggest that spinal circuits, which implement supraspinal control signals for muscle contraction, are capable of further modifying MCX actions in an activity-dependent manner.
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