伤口愈合
组织重塑
医学
病态的
再生(生物学)
过程(计算)
神经科学
生物信息学
病理
生物
炎症
外科
细胞生物学
计算机科学
免疫学
操作系统
作者
Amanda Spielman,Michelle Griffin,Jennifer Parker,Asha C. Cotterell,Derrick C. Wan,Michael T. Longaker
出处
期刊:Advances in wound care
[Mary Ann Liebert]
日期:2023-02-01
卷期号:12 (2): 57-67
被引量:13
标识
DOI:10.1089/wound.2022.0049
摘要
Significance: Increasing development of experimental animal models has allowed for the study of scar formation. However, many pathophysiological unknowns remain in the longest stage of healing, the remodeling stage, which may continue for a year or more. The wound healing process results in different types of scarring classified as normal or pathological depending on failures at each stage. Failures can also occur during wound remodeling, but the molecular mechanisms driving the wound remodeling process have yet to be investigated. Recent Advances: While the current understanding of wound repair is based on investigations of acute healing, these experimental models have informed knowledge of key components of remodeling. This review examines the components that contribute to collagen organization and the final scar, including cell types, their regulation, and signaling pathways. Dysregulation in any one of these components causes pathologic healing. Critical Issues and Future Directions: As wounds continue to remodel months to years after reepithelialization, new models to better understand long-term remodeling will be critical for improving healing outcomes. Further investigation of the contributions of fibroblasts and cell signaling pathways involved during remodeling as well as their potential failures may inform new approaches in promoting regenerative healing beyond reepithelialization.
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