Sigma-1受体
西格玛受体
受体
西格玛
多巴胺能
神经保护
化学
药理学
多巴胺受体D3
多巴胺受体
生物
生物化学
神经科学
多巴胺
物理
量子力学
兴奋剂
标识
DOI:10.2174/0929867322666150114163607
摘要
Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its molecular size is about 18 kDa. Recent studies indicated that sigma-2 receptor modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced addiction behavior. Some sigma-2 receptor ligands (ditolylguanidine, afobazole, etc) display the neuroprotective effect. Although sigma-2 receptor hasn’t been cloned, tens of sigma-2 receptor ligands, which demonstrate high affinity and selectivity, have been identified in the past decade. In this review, we mainly focus on these series of selective sigma-2 receptor ligands, their neuropsychological effects, and molecular probes for tracing sigma-2 receptors in central nervous system. Keywords: Addiction, calcium, neuroprotection, probe, sigma-2 receptor.
科研通智能强力驱动
Strongly Powered by AbleSci AI