化学
细胞周期蛋白依赖激酶7
效力
药效团
药理学
生物化学
计算生物学
细胞周期
细胞
体外
医学
细胞周期蛋白依赖激酶2
生物
作者
Jason Marineau,Kristin B. Hamman,Shanhu Hu,Sydney Alnemy,Janessa Mihalich,A. Kabro,Kenneth Matthew Whitmore,Dana K. Winter,Stéphanie Roy,Stéphane Ciblat,Nan Rosemary Ke,Anneli Savinainen,Ashraf Wilsily,G. Malojcic,Robert Zahler,Darby Schmidt,Michael J. Bradley,Nigel J. Waters,Claudio Chuaqui
标识
DOI：10.1021/acs.jmedchem.1c01171
摘要
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of
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