Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients

生物 免疫系统 免疫学 免疫性血小板减少症 发病机制 自身免疫性疾病 脾切除术 医学 促炎细胞因子 调节性T细胞 自身免疫 细胞因子 血小板 脾脏 抗体 炎症 T细胞 白细胞介素2受体
作者
Xiaofeng Wang,Feng Li,Yang Li,Lihua Sun,Yahong Meng,Xiaohong Fan,Xuelian Wang,Duojiao Wu,Yunfeng Cheng,Fanli Hua
出处
期刊:Journal of Leukocyte Biology [Oxford University Press]
卷期号:110 (2): 335-341 被引量:5
标识
DOI:10.1002/jlb.5ab0521-621rr
摘要

Abstract Immune thrombocytopenia (ITP) is an autoimmune-mediated disease characterized by decreased platelet counts. Cytokines play important roles in modulating the immune response and are involved in the pathogenesis of many autoimmune diseases. This study aimed at exploring the serum levels of a core set of cytokines that exert immune-regulatory functions in newly diagnosed ITP patients (both before and after treatment) and splenectomized ITP patients. Using the Bio-Plex suspension array system and ELISA, the serum levels of IL-10, IL-21, IL-27, IL-33, IL-35, IL-37, and TGF-β1 were detected. The data showed that the serum levels of the immune regulatory cytokines IL-10, IL-35, and TGF-β1 were significantly lower in newly diagnosed ITP patients. Decreased cytokine levels could be improved in patients with a complete response or a response after steroid-based treatment(s). The serum concentrations of TGF-β1 were positively correlated with the platelet counts both before and after treatment. All the detected immune-regulatory cytokines, except IL-37, showed significantly higher levels in splenectomized ITP patients than pretreatment ITP patients and healthy controls. In conclusion, these data suggest that lower levels of immune-regulatory cytokines are involved in the pathogenesis of ITP and that there is a long-lasting overexpression of immune-regulatory cytokines in ITP patients with splenectomy.
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