化学
连续流动
碎片(计算)
光化学
组合化学
光解
荧光
计算机科学
机械
量子力学
操作系统
物理
作者
Pablo Wessig,Saskia Krebs
标识
DOI:10.1002/ejoc.202100955
摘要
Abstract The photochemical fragmentation of N‐aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous‐flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by‐products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.
科研通智能强力驱动
Strongly Powered by AbleSci AI