Thrombus Histology as It Relates to Mechanical Thrombectomy: A Meta-Analysis and Systematic Review

医学 血栓 组织学 荟萃分析 外科 病理
作者
Ankur Bhambri,Arjun Adapa,Yang Liu,Tobias Boeckh‐Behrens,Václav Procházka,Francisco Hernández-Fernández,Rosa Angélica Barbella-Aponte,Tetsuya Hashimoto,Luis Savastano,Joseph J. Gemmete,Neeraj Chaudhary,Albert J. Shih,Aditya S. Pandey
出处
期刊:Neurosurgery [Oxford University Press]
卷期号:89 (6): 1122-1131 被引量:17
标识
DOI:10.1093/neuros/nyab366
摘要

Appropriate thrombus-device interaction is critical for recanalization. Histology can serve as a proxy for mechanical properties, and thus inform technique selection.To investigate the value of histologic characterization, we conducted a systematic review and meta-analysis on the relationship between thrombus histology and recanalization, technique, etiology, procedural efficiency, and imaging findings.In this meta-analysis, we identified studies published between March 2010 and March 2020 reporting findings related to the histologic composition of thrombi in large vessel occlusion stroke. Studies with at least 10 patients who underwent mechanical thrombectomy using stent retriever or aspiration were considered. Only studies in which retrieved thrombi were histologically processed were included. Patient-level data were requested when data could not be directly extracted. The primary outcome assessed was the relationship between thrombus histology and angiographic outcome.A total of 22 studies encompassing 1623 patients met inclusion criteria. Clots associated with good angiographic outcome had higher red blood cell (RBC) content (mean difference [MD] 9.60%, 95% CI 3.85-15.34, P = .008). Thrombi retrieved by aspiration had less fibrin (MD -11.39, 95% CI -22.50 to -0.27, P = .046) than stent-retrieved thrombi. Fibrin/platelet-rich clots were associated with longer procedure times (MD 13.20, 95% CI 1.30-25.10, P = .037). Hyperdense artery sign was associated with higher RBC content (MD 14.17%, 95% CI 3.07-25.27, P = .027). No relationship was found between composition and etiology.RBC-rich thrombi were associated with better recanalization outcomes and shorter procedure times, suggesting that preinterventional compositional characterization may yield important prognostic and therapeutic guidance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
llllxj完成签到,获得积分20
刚刚
Lucas应助江月年采纳,获得10
1秒前
丘比特应助刘浩然采纳,获得10
1秒前
害羞含雁发布了新的文献求助10
1秒前
2秒前
小蘑菇应助宋祯丞采纳,获得10
2秒前
忧郁的香魔完成签到,获得积分10
2秒前
hull发布了新的文献求助10
2秒前
2秒前
思源应助LKLK采纳,获得10
3秒前
英姑应助科研采纳,获得10
3秒前
3秒前
4秒前
爆米花应助cknckn11采纳,获得30
4秒前
5秒前
5秒前
在险峰完成签到 ,获得积分10
5秒前
崔昕雨完成签到,获得积分10
5秒前
archer01发布了新的文献求助10
6秒前
栗子发布了新的文献求助10
6秒前
6秒前
6秒前
iu1392发布了新的文献求助10
7秒前
Arthur完成签到,获得积分10
7秒前
手可摘星辰完成签到,获得积分0
8秒前
好运藏在善良里应助小猪采纳,获得20
8秒前
8秒前
8秒前
老解完成签到 ,获得积分10
9秒前
9秒前
小鑫完成签到,获得积分10
9秒前
科研新手完成签到,获得积分10
9秒前
ash发布了新的文献求助10
10秒前
10秒前
11秒前
浩多多完成签到,获得积分10
11秒前
莴苣发布了新的文献求助10
11秒前
11秒前
邓佳鑫Alan应助江南第八采纳,获得10
11秒前
12秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546888
求助须知:如何正确求助?哪些是违规求助? 3123917
关于积分的说明 9357332
捐赠科研通 2822504
什么是DOI,文献DOI怎么找? 1551513
邀请新用户注册赠送积分活动 723546
科研通“疑难数据库(出版商)”最低求助积分说明 713791