Liver resection is justified for multinodular hepatocellular carcinoma in selected patients with cirrhosis: A multicenter analysis of 1,066 patients

医学 肝细胞癌 肝硬化 围手术期 胃肠病学 切除术 内科学 肝切除术 放射科 外科
作者
Zhenli Li,Jiong-Jie Yu,Junwu Guo,Chengjun Sui,Binghua Dai,Wanguang Zhang,Ting‐Hao Chen,Chao Li,Wei‐Min Gu,Ya-Hao Zhou,Hong Wang,Yaoming Zhang,Xianhai Mao,Timothy M. Pawlik,Ming-Da Wang,Lei Liang,Han Wu,Wan Yee Lau,Mengchao Wu,Feng Shen
出处
期刊:Ejso [Elsevier BV]
卷期号:45 (5): 800-807 被引量:16
标识
DOI:10.1016/j.ejso.2018.12.016
摘要

Background The role of liver resection for multinodular (≥3 nodules) hepatocellular carcinoma (HCC) remains unclear, especially among patients with severe underlying liver disease. We sought to evaluate surgical outcomes among patients with cirrhosis and multinodular HCC undergoing liver resection. Methods Using a multicenter database, outcomes among cirrhotic patients who underwent curative-intent resection of HCC were examined stratified according to the presence or absence of multinodular disease. Perioperative mortality and morbidity, as well as overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups. Results Among 1066 cirrhotic patients, 906 (85.0%) had single- or double-nodular HCC (the non-multinodular group), while 160 (15.0%) had multinodular HCC (the multinodular group). There were no differences in postoperative 30-day mortality and morbidity among non-multinodular versus multinodular patients (1.8% vs. 1.9%, P = 0.923, and 36.0% vs. 39.4%, P = 0.411, respectively). In contrast, 5-year OS and RFS of multinodular patients were worse compared with non-multinodular patients (34.6% vs. 58.2%, and 24.7% vs. 44.5%, both P < 0.001). On multivariable analyses, tumor numbers ≥5, total tumor diameter ≥8 cm and microvascular invasion were independent risk factors for decreased OS and RFS after resection of multinodular HCC in cirrhotic patients. Conclusions Liver resection can be safely performed for multinodular HCC in the setting of cirrhosis with an overall 5-year survival of 34.6%. Tumor number ≥5, total tumor diameter ≥8 cm and microvascular invasion were independently associated with decreased OS and RFS after resection in cirrhotic patients with multinodular HCC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
深情安青应助tyy采纳,获得10
刚刚
丘比特应助Dale采纳,获得10
刚刚
1秒前
1秒前
蛋挞发布了新的文献求助10
1秒前
hhchhcmxhf完成签到,获得积分10
1秒前
Jene完成签到 ,获得积分20
1秒前
钮卿发布了新的文献求助10
2秒前
齐天完成签到 ,获得积分10
2秒前
3秒前
3秒前
三金发布了新的文献求助10
4秒前
Scarecrow发布了新的文献求助10
4秒前
沉静的松发布了新的文献求助10
4秒前
慈祥的爆米花完成签到,获得积分10
4秒前
大好河山发布了新的文献求助10
4秒前
rainbow5432完成签到 ,获得积分10
6秒前
6秒前
guyutian完成签到,获得积分10
6秒前
7秒前
吴1完成签到,获得积分10
7秒前
Icy发布了新的文献求助100
7秒前
8秒前
Owen应助科研通管家采纳,获得10
8秒前
Hello应助科研通管家采纳,获得10
9秒前
阳光的问雁完成签到,获得积分20
9秒前
ll应助科研通管家采纳,获得10
9秒前
鹿lu应助科研通管家采纳,获得10
9秒前
Lucas应助科研通管家采纳,获得10
9秒前
Lucas应助科研通管家采纳,获得10
9秒前
研友_VZG7GZ应助科研通管家采纳,获得10
9秒前
FashionBoy应助科研通管家采纳,获得10
9秒前
orixero应助科研通管家采纳,获得10
9秒前
JamesPei应助科研通管家采纳,获得10
9秒前
9秒前
9秒前
9秒前
青山松下关注了科研通微信公众号
10秒前
顾矜应助shinn采纳,获得10
10秒前
神勇契完成签到,获得积分10
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969398
求助须知:如何正确求助?哪些是违规求助? 3514239
关于积分的说明 11173064
捐赠科研通 3249531
什么是DOI,文献DOI怎么找? 1794934
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804827