Probiotic supplementation during pregnancy and early childhood in the prevention of atopic dermatitis: A literature review

Event Abstract Back to Event Probiotic supplementation during pregnancy and early childhood in the prevention of atopic dermatitis: A literature review Kang Nien How1*, Zee Wei Lai2 and Pui Ling Thong1 1 Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia 2 Taylor's University, Malaysia Background Atopic dermatitis (AD) is an increasingly prevalent chronic skin disorder that results in progression to atopic march. The hygiene theory has been postulated to have caused the rise in the incidence of atopic diseases among urban living. Early alteration of gut microbiota has been postulated to have immuno-regulatory effects, causing reduction in the incidence of atopic dermatitis. A literature search was therefore performed on randomized controlled trials that evaluate the effects of probiotic supplementation during pregnancy and early infancy in the prevention of atopic dermatitis. Methods To assess the effects of probiotic supplementation during pregnancy and early infancy in the prevention of AD in children, PubMed database was searched for randomized controlled trials that were published in English language. Results Based on the search string, a total of 236 articles were identified. Two studies were further identified after listing the references of existing meta-analysis or systematic review. After going through the inclusion and exclusion criteria, a total of 14 studies comprising of 4712 subjects were included in the final analysis. Lactobacillus spp were used in 5 studies, Bifidobacterium spp. in 2 studies and a combination of probiotic strains in 8 studies. Probiotics were mainly initiated for 4-6 weeks before delivery and continued postnatally for an average of 6 months. Eight out of the 14 articles demonstrated a significant reduction in the incidence of atopic dermatitis in the probiotic arm. A combination of probiotic strains appeared to be superior when compared to a single strain probiotic in the prevention of atopic dermatitis. Conclusion Probiotics appeared to have a protective role in AD prevention if initiated during pregnancy and early infancy. Further analysis of the current data is, however, required. Keywords: atopic dermatitis, probiotic, pregnant, Lactobacillus, Bifidobacterium Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Oral Presentation Topic: Inflammatory diseases Citation: How K, Lai Z and Thong P (2019). Probiotic supplementation during pregnancy and early childhood in the prevention of atopic dermatitis: A literature review. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00085 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Kang Nien How, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia, hkangnien@upm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kang Nien How Zee Wei Lai Pui Ling Thong Google Kang Nien How Zee Wei Lai Pui Ling Thong Google Scholar Kang Nien How Zee Wei Lai Pui Ling Thong PubMed Kang Nien How Zee Wei Lai Pui Ling Thong Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.