光刻胶
微流控
堆积
胶水
稀释
纳米技术
化学
混合(物理)
制作
光电子学
图层(电子)
复合材料
材料科学
医学
热力学
物理
量子力学
病理
有机化学
替代医学
作者
María F. Mora,Carlos D. Garcı́a,Federico Schaumburg,Pablo A. Kler,Claudio L. A. Berli,Michinao Hashimoto,Emanuel Carrilho
标识
DOI:10.1021/acs.analchem.9b01020
摘要
This work describes a method to fabricate three-dimensional paper microfluidic devices in one step, without the need of stacking layers of paper, glue, or tape. We used a nontransparent negative photoresist that allows patterning selectively (vertically) the paper, creating systems of two or three layers, including channels. To demonstrate the capabilities of this methodology, we designed, fabricated, and tested a six-level diluter. The performance of the device was also simulated using a simple numerical model implemented in the program PETSc-FEM. The resulting μPAD is small (1.6 cm × 2.2 cm), inexpensive, requires low volumes of sample (5 μL), and is able to perform mixing and dilution in 2 min.
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