Effects of Quercetin and Apigenin on Serum Uric Acid and Antioxidant Capacity in Hyperuricemic Rats

Objective: To study the effects of quercetin(Que) and apigenin(Api) at the same dose on blood uric acid and antioxidant capacity in hyperuricemic rats induced by adenine combined with ethambutol hydrochloride.Methods: SD rats were divided into 5 groups,normal control,model control,allopurinol group,Que group,and Api group.Hyperuricemia and renal failure in rats were induced by adenine and ethambutol hydrochloride tablets intragastrically,and then Que and Api were separately administrated for 3 weeks.Enzyme activity and serum biochemical indicators in liver and serum were measured at the end of 21-day administration.Results: Que and Api could effectively lower the levels of serum uric acid(SUA),serum urea nitrogen(SUN),serum creatinine(SCr) and malondialdehyde(MDA),and elevate the activity of superoxide dismutase(SOD) and total antioxidant capacity(T-AOC) in serum and liver.Conclusion: Que and Api can reduce serum uric acid and lipid peroxidation level so as to improve antioxidant and free radical scavenging capacities in hyperuricemic rats.