Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

医学 产科 三体 妇科 双胎妊娠 产前诊断 怀孕 预测值 辅助生殖技术 假阳性率 妊娠期 胎儿 生物 内科学 不育 统计 遗传学 数学
作者
Yue‐Qiu Tan,Ya Gao,Ge Lin,Meili Fu,Xihong Li,Xuyang Yin,Juan Du,Jing Li,Wen Li,Huanhuan Peng,Yuying Yuan,Fang Chen,Fuman Jiang,Hongyun Zhang,Guangxiu Lu,Fei Gong,Wei Wang
出处
期刊:Prenatal Diagnosis [Wiley]
卷期号:36 (7): 672-679 被引量:55
标识
DOI:10.1002/pd.4837
摘要

Abstract Objective The objective of the study is to report the performance of noninvasive prenatal testing (NIPT) in twin pregnancies after the treatment of assisted reproductive technology (ART). Method In two years period, 565 pregnant women with ART twin pregnancies were prospectively tested by NIPT for screening for trisomy 21 (T21), 18 (T18), and 13 (T13) by sequencing cell‐free DNA in maternal plasma. Positive NIPT results were confirmed by karyotyping, while negative results were interviewed after delivery. Pregnant decision based on NIPT and confirmation results was discussed during post‐test counseling. Results In total of 565 cases, NIPT had a failure rate of 0.9% (5/565). Four cases of T21 were identified by NIPT and confirmed by karyotyping, resulting in 100% (95%CI 39.8%–100%) positive predictive value. Among 556 cases with NIPT negative results, 506 cases (91.0%) were confirmed by follow‐up of postnatal phenotypes, while 33 cases (5.9%) had adverse pregnant outcomes with unconfirmed reasons because of the lack of cytogenetic samples. The remaining 17 cases (3.1%) refused follow‐up. No false negative result was reported. Conclusion With apparently high positive predictive value and low false positive rate, NIPT has the potential to be used as a good alternative approach of conventional prenatal screening at the first trimester in ART twin pregnancy. © 2016 John Wiley & Sons, Ltd.
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