纳米点
光热治疗
材料科学
纳米材料
纳米技术
相(物质)
激光器
消光(光学矿物学)
光电子学
光学
化学
矿物学
物理
有机化学
作者
Zhan Zhou,Bowen Li,Chuang Shen,Di Wu,Huacheng Fan,Jiangqi Zhao,Hai Li,Zhiyuan Zeng,Zhimin Luo,Lu‐Fang Ma,Chaoliang Tan
出处
期刊:Small
[Wiley]
日期:2020-10-01
卷期号:16 (43)
被引量:170
标识
DOI:10.1002/smll.202004173
摘要
Abstract Transition metal dichalcogenide (TMD) nanomaterials, specially MoS 2 , are proven to be appealing nanoagents for photothermal cancer therapies. However, the impact of the crystal phase of TMDs on their performance in photoacoustic imaging (PAI) and photothermal therapy (PTT) remains unclear. Herein, the preparation of ultrasmall single‐layer MoS 2 nanodots with different phases (1T and 2H phase) is reported to explore their phase‐dependent performances as nanoagents for PAI guided PTT in the second near‐infrared (NIR‐II) window. Significantly, the 1T‐MoS 2 nanodots give a much higher extinction coefficient (25.6 L g −1 cm −1 ) at 1064 nm and subsequent photothermal power conversion efficiency (PCE: 43.3%) than that of the 2H‐MoS 2 nanodots (extinction coefficient: 5.3 L g −1 cm −1 , PCE: 21.3%). Moreover, the 1T‐MoS 2 nanodots also give strong PAI signals as compared to negligible signals of 2H‐MoS 2 nanodots in the NIR‐II window. After modification with polyvinylpyrrolidone, the 1T‐MoS 2 nanodots can be used as a highly efficient agent for PAI guided PTT to effectively ablate cancer cells in vitro and tumors in vivo under 1064 nm laser irradiation. This work proves that the crystal phase plays a key role in determining the performance of nanoagents based on TMD nanomaterials for PAI guided PTT.
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