Calorie restriction during gestation affects ovarian reserve in offspring in the mouse

后代 妊娠期 生物 断奶 卵泡发生 内分泌学 毛囊 内科学 窦卵泡 怀孕 卵巢 卵巢储备 男科 哺乳期 医学 遗传学 不育
作者
Bianka M. Zanini,Kelvin R. S. Andrade,Jorgea Pradieé,Gabriel Barreto Veiga,Driele N. Garcia,Rafael Gianella Mondadori,Luis A. Cruz,Joao Alveiro Alvarado Rincón,Renata Pereira Ramirez,Tatiana D. Saccon,Michał M. Masternak,Carlos Castilho Barros,Augusto Schneider
出处
期刊:Reproduction, Fertility and Development [CSIRO Publishing]
卷期号:32 (18): 1338-1338 被引量:3
标识
DOI:10.1071/rd20107
摘要

The aim of this study was to investigate the effect of calorie restriction (CR) during pregnancy in mice on metabolism and ovarian function in the offspring. Pregnant female mice were divided into two groups, a control group and a CR group (n=7 in each). Mice in the CR group were fed 50% of the amount consumed by control females from Day 10 of gestation until delivery. After weaning, the offspring received diet ad libitum until 3 months of age, when ovaries were collected. Ovaries were serially cut and every sixth section was used for follicle counting. Female offspring from CR dams tended to have increased bodyweight compared with offspring from control females (P=0.08). Interestingly, fewer primordial follicles (60% reduction; P=0.001), transitional follicles (P=0.0006) and total follicles (P=0.006) were observed in offspring from CR mothers. The number of primary, secondary and tertiary follicles did not differ between the groups (P>0.05). The CR offspring had fewer DNA double-strand breaks in primary follicle oocytes (P=0.03). In summary, CR during the second half of gestation decreased primordial ovarian follicle reserve in female offspring. These findings suggest that undernutrition during the second half of gestation may decrease the reproductive lifespan of female offspring.
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