Dietary lycopene alters the expression of antioxidant enzymes and modulates the blood lipid profile of pigs

番茄红素 抗氧化剂 过氧化氢酶 谷胱甘肽过氧化物酶 超氧化物歧化酶 化学 动物科学 类胡萝卜素 氧化应激 内分泌学 饲料转化率 内科学 食品科学 生物 生物化学 医学 体重
作者
Marcelise Regina Fachinello,Eliane Gasparino,André Vinícius Sturzenegger Partyka,Angélica de Souza Khatlab,Leandro Dalcin Castilha,Laura Marcela Díaz Huepa,Leonardo Felipe Malavazi Ferreira,Paulo César Pozza
出处
期刊:Animal Production Science [CSIRO Publishing]
卷期号:60 (6): 806-806 被引量:4
标识
DOI:10.1071/an18456
摘要

Lycopene has the highest antioxidant activity among carotenoids due to its high number of conjugated double bonds; thus, it can be used in pig diets to look for improvements in growth performance and health status, eliminating or preventing the formation of free radicals. Therefore, the aim of the present study was to investigate the effects of dietary lycopene on the growth performance, the gene expression of antioxidant enzymes and blood lipid profile of finishing pigs. In total, 40 barrows and 40 gilts (Piétrain × Landrace × Large White) were used, averaging 75.04 ± 1.6 kg of initial bodyweight. Pigs were distributed in a 2 × 5 factorial arrangement, consisting of two genders (male and female) and five dietary levels of lycopene (0, 12.5, 25.0, 37.5 and 50.0 mg/kg of diet) supplemented for 28 days. It was observed that gilts presented with average daily feed intake (P = 0.001) being lower and the gain:feed ratio (P = 0.001) higher than for barrows. Increasing dietary lycopene concentration provided a linear decrease in the gene expression of the enzymes superoxide dismutase (SOD1; P = 0.018) and catalase (P = 0.001) in the liver of gilts. The gilts showed a lower gene expression than did barrows for SOD1 gene (P = 0.001) receiving 50.0 mg lycopene/kg of diet and for catalase gene (P = 0.001) receiving of 0, 12.5 and 50.0 mg lycopene/kg of diet. Glutathione peroxidase showed a lower expression (P = 0.001) for gilts than for barrows. Total cholesterol, low-density lipoprotein (LDL) and LDL:high-density lipoprotein (HDL) ratio decreased (P = 0.001) as lycopene concentration increased in the diet. Increasing dietary lycopene in pig diets improved the lipid profile of the blood plasma, providing an increase in the concentration of high-density lipoprotein (HDL; P = 0.001). Gilts had greater plasma concentrations of urea (P = 0.001) and triglycerides (P = 0.001) and lower concentrations of HDL (P = 0.001), LDL (P = 0.001) and a lower LDL:HDL ratio (P = 0.004) than did barrows. Dietary lycopene up to 50 mg/kg does not affect the growth performance of pigs, acting as a potent modulator of the lipid profile and also reducing the plasma concentrations of total cholesterol and low-density lipoproteins, while increasing the high-density lipoproteins. In addition, lycopene also reduces the gene expression of superoxide dismutase and catalase enzymes in the liver of gilts.
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